Molecular mechanisms associated with long-term survival after pancreatic cancer surgery
Survival after surgery for pancreatic cancer varies greatly and is influenced by factors such as local tumour growth and lymph-node involvement. This study investigates biological differences between patients who survive for a long time after surgery and those whose survival is shorter. Earlier work has already identified differences in their immune systems.
Tumour samples from both groups are analysed using NanoString technology. Researchers compare genetic activity, determine the function of the genes involved and validate the differences they find.
The aim is to identify targets for new treatments that could improve survival for future patients.