| Title / Author | Publication (Epub) date | Journal | |
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ZEB1, a novel junctional adhesion molecule A regulator, impacts sensitivity of pancreatic cancer-associated fibroblasts to reovirus Dam N, Harryvan TJ, Dang H, Ioannidis G, Schmierer B, Hawinkels LJAC, Kemp V. |
18-12-2025 | Molecular Therapy Oncology | Read Article |
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REACTIVe-2: phase I evaluation of dendritic cell vaccination and agonistic CD40 therapy following (m)FOLFIRINOX in metastatic pancreatic cancer Songul Kucukcelebi, Freek R. van Eijck Land, Sjoerd H. van der Burg, Ferry A. L. M. Eskens, Marjolein Y. V. Homs, Marcella Willemsen, Anne Onrust-van Schoonhoven, Nina E. M. Rozendaal, Amine Fellah, Disha Vadgama, Miranda Moskie, Koen Bezemer, Mikhail Doukas, Casper W. van Eijck, Ralph Stadhouders, Judith de Vos-Geelen, Aniek E. van Diep, Ilona Enninga, Rob Meijer, Sumeet V. Ambarkhane, Peter Ellmark, Joachim G. J. V. Aerts, Christianne Groeneveldt & Casper H. van Eijck |
28-11-2025 | Nature Communications, 2025 | Read Article |
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Alphavirus replicans encoding IFN-γ enhancement cancer virotherapy by overcoming macrophage-mediated suppression. Horvathova L, Kinderman P, Janzen T, Hoogeboom BN, Weissing FJ, van Montfoort N, Daemen T, Bhatt DK. |
17-10-2025 | iScience | Read Article |
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Cell-derived Newcastle disease virus variant with two amino acid substitutes near cleavage site of F shows favorable traits as uncolytic virus Huberts M, de Graaf JF, Groeneveld D, van Nieuwkoop S, Fouchier RAM, van den Hoogen BG. |
06-12-2024 | Molecular Therapy Oncology. 2024 | Read Article |
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Dendritic Cell-Based Immunotherapy in Patients With Resected Pancreatic Cancer van 't Land FR, Willemsen M, Bezemer K, et al. |
10-09-2024 | Journal of Clinical Oncology. 2024 | Read Article |
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Preclinical evaluation of the gorilla-derived HAdV-B AdV-lumc007 oncolytic adenovirus "GoraVir" for the treatment of pancreatic ductal adenocarcinoma. Bots STF, Harryvan TJ, Groeneveldt C, Kinderman P, Kemp V, van Montfoort N, Hoeben RC. |
31-05-2024 | Molecular Oncology. 2024 | Read Article |
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Octyl itaconate factors VSVΔ51 uncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways. Kurmasheva N, Said A, Wong B, Kinderman P, Han X, Rahimic AHF, Kress A, Carter-Timofte ME, Holm E, van der Horst D, Kollmann CF, Liu Z, Wang C, Hoang HD, Kovalenko E, Chrysopoulou M, Twayana KS, Ottosen RN, Svenningsen EB, Begnini F, Kiib AE, Kromm FEH, Weiss HJ, Di Carlo D, Muscolini M, Higgins M, van der Heijden M, Bardoul A, Tong T, Ozsvar A, Hou WH, Schack VR, Holm CK, Zheng Y, Ruzek M, Kalucka J, de la Vega L, Elgaher WAM, Korshoej AR, Lin R, Hiscott J, Poulsen TB, O'Neill LA, DG, Rinschen MM, from Montflo, Din, Oinfnieer |
15-05-2024 | Nature Communications. 2024 | Read Article |
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The heterogeneous sensitivity of paediatric brain tumors to different oncolytic viruses is predicted by unique gene expression profiles Vazaios K, Stavrakaki Ε, Vogelezang LB, Ju J, Waranecki P, Mason DS, Meel MH, Kemp V, van den Hoogen BG, Hoeben RC, Chiocca EA, Goins WF, Stubbs A, Li Y, Alonso MM, Calkoen FG, Hulleman E, van der Lugt J, Lamfers MLM. |
15-04-2024 | Molecular Therapy. 2024 | Read Article |
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An autologous ex vivo model for exploring patient-specific responses to viro-immunotherapy in glioblastoma. Stavrakaki E, van den Bossche WBL, Vogelezang LB, Teodosio C, Mustafa DM, van Dongen JJM, Dirven CMF, Balvers RK, Lamfers ML. |
25-03-2024 | Cell Reports Methods. 2024 | Read Article |
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Neutralizing antibodies impair the uncolytic efficacy of reovirus but allow effective combination with T cell-based immunotherapy Groeneveldt C, Kinderman P, Griffioen L, Rensing O, Labrie C, van den Wollenberg DJM, Hoeben RC, Coffee M, Loghmani H, Verdegaal EME, Welters MJP, van der Burg SH, van Hall T, van Montfoort N. |
04-03-2024 | Cancer Immunology Research. 2024 | Read Article |
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A liquid biomarker signature of inflammatory proteins accurately predicts early pancreatic cancer progression during FOLFIRINOX chemotherapy. of Eijck CWF, Sabroso-Lasa S, String GJ, Mustafa DAM, Fellah A, Koerkamp BG, Malats N, van Eijck CHJ. |
31-01-2024 | Neoplasia. 2024 | Read Article |
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FOLFIRINOX chemotherapy modulators the peripheral immune landscape in pancreatic cancer: Implications for combination therapies and early response prediction Casper W.F. van Eijck, Gaby Strijk, Eveline E. Vietsch, Fleur van der Sijde, Maaike Verheij, Dana A.M. Mustafa, Madelief Vink, Joachim G.J.V. Aerts, Casper H. J. van Eijcka, Marcella Willemsen |
17-11-2023 | European Journal of Cancer | Read Article |
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B cell immune profiles in dysbiotic vermiform appendixes of pancreatic cancer patients Eveline E. Vietsch, Diba Latifi, Maaike Verheij, Elise W.A. van der Oost, Roeland F. de Wilde, Roel Haen, Anne Loes van den Boom, Bas Groot Koerkamp, Pascal G. Doornebosch, Victorien M.T. van Verschuer, Ariadne H.A.G. Ooms, Farzana Mohammad, Marcella Willemsen, Joachim G.J.V. Aerts, Ricki T. Krog, Noel F.C. de Miranda, Thierry P.P. van den Bosch, Yvonne M. Mueller, Peter D. Katsikis and Casper H.J. van Eijck |
10-11-2023 | Frontiers | Read Article |
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Overexpression of the adhesion signaling pathway is linked to short-term survival in pancreatic ductal adenocarcinoma M.H. Aziz, L. Saida, C.H.J. van Eijck, D.A.M. Mustafa b |
01-11-2023 | Elsevier, Pancreatilogy | Read Article |
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Analyzing Flow Cytotry or Targeted Gene Expression Data Influences Clinical Discoveries. Willem de Koning, Casper W. F. van Eijck, Fleur van der Sijde, Gaby J. Strijk, Astrid A. M. Oostvogels, Reno Debets, Casper H. J. van Eijck, and Dana A. M. Mustafa |
31-08-2023 | Cancers | Read Article |
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Enhanced antitumour immunity following neoadjuvant chemoradiotherapy mediates a favorable prognosis in women with resected pancreatic cancer Casper W F van Eijck, Dana A M Mustafa, Disha Vadgama, Noel F C de Miranda, Bas Groot Koerkamp, Geertjan van Tienhoven, Sjoerd H van der Burg, Núria Malats Cancer Group (DPCG), Casper H J van Eijck, Dutch Pancreatic |
01-08-2023 | BMJ Journals | Read Article |
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Rintatolimod: a potential treatment in patients
with pancreatic cancer expressing Toll-like receptor 3 Hassana El Haddaoui, Casper WF van Eijck, Mikhail Doukas, Thierry PP van den Bosch, Peter M van Koetsveld, Leo J Hofland, Dana AM Mustafa, Casper HJ van Eijck. |
15-06-2023 | American Journal of Cancer Research | Read Article |
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Immunostimulatory Profile of Cancer Cell Death Induced by the AdV-Lumc007-Derived Oncolytic Virus Selas T. F. Bots, Sanne L. Landman, Martijn J. W. E. Rabelink, Diana J. M. van den Wollenberg and Rob C. Hoeben |
19-01-2023 | Viruses | Read Article |
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Preclinical evaluation of the gorilla-derived HAdV-B AdV-lumc007 oncolytic adenovirus Selas T.F. Bots, Tom J. Harryvan, Christianne Groeneveldt, Priscilla Kinderman, Vera Kemp, Nadine van Montfoort, and Rob C. Hoeben |
2023 | Molecular Oncology | Read Article |
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A multigene circulating biomarker to predict the lick of FOLFIRINOX response after a single cycle in patients with pancreatic ductal adenocarcinoma Casper W.F. van Eijck, Willem de Koning, Fleur van der Sijde, Miranda Moskie, Bas Groot Koerkamp, Marjolein Y.V. Homs, Sjoerd H. van der Burg, Casper H.J. van Eijck, Dana A.M. Mustafa |
28-12-2022 | Cancers | Read Article |
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Genome Analyses of Ten New Ape Adenoviruses with Similarity to Human Mastadenovirus C Selas T. F. Bots, Vera Kemp, Iris J. C. Dautzenberg and Rob C. Hoeben |
30-08-2022 | International Journal of Molecular Science | Read Article |
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Comparison between intratumoural and intravenously administered oncolytic virus therapy with Newcastle disease virus in a xenograft murine model for pancreatic adenocarcinoma J. Frederique de Graaf, Marco Huberts, Daphne Groeneveld, Stefan van Nieuwkoop, Casper H.J. van Eijck, Ron A.M. Fouchier, Bernadette G. van den Hoogen |
05-07-2022 | Heliyon | Read Article |
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Optimizing environmental safety and cell-killing potential of uncolytic Newcastle disease virus with modifications of the V, F and HN genes J. Frederique de Graaf, Stefan van Nieuwkoop, Theo Bestebroer, Daphne Groeneveld, Casper H. J. van Eijck, Ron A. M. Fouchier, Bernadette G. van den Hoogen |
09-02-2022 | Plos One | Read Article |
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Robust deep learning model for prognostic stratification of pancreatic ductal adenocarcinoma patients. Jie Ju, Leonoor V. Wismans, Dana A.M. Mustafa, Marcel J.T. Reinders, Casper H.J. van Eijck, Andrew P. Stubbs & Yunlei Li. |
17-12-2021 | iScience | Read Article |
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Non-human primate adenoviruses of the Human Adenovirus B species are potent and generally-acting oncolytic vector candidates Ms. Selas TF Bots, Dr. Vera Kemp, Mr. Steve J Cramer, Dr. Diana JM van den Wollenberg, Dr. Marten Hornsveld, Dr. Martine Lamfers, Dr. Gabri van der Pluijm, and Prof. Rob C Hoeben |
03-12-2021 | Human Gene Therapy | Read Article |
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Organoids brought from neoadjuvant FOLFIRINOX patients relapse therapy resistance in pancreatic ductal adenocarcinoma Elham Aida Farshadi, Jiang Chang, Brad Sampadi, Mikhail Doukas, Freek Van иt Land, Fleur van der Sijde, Eveline E. Vietsch, Joris Pothof, Bas Groot Koerkamp, Casper H.J. van Eijck. |
27-09-2021 | Clinical Cancer Research | Read Article |
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The Multifaceted Role of Macrophages in Uncolytic Virotherapy. Hofman L, Lawler SE, Lamfers MLM. |
13-08-2021 | Viruses | Read Article |
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The Role of the Respiratory Microbiome and Viral Presence in Lower Respiratory Tract Infection Severity in the First Five Years of Life Ivo Hoefnails, Josephine van de Maat, Jeroen J.A. van Kampen, Annemarie van Rossum, Charlie Obihara, Gerdien A. Tramper-Stranders, Astrid P. Heikema, Willem de Koning, Anne-Marie van Wermerkerken, Deborah Horst-Kreft, Gertjan J.A. Driessen, Janine Punt, Frank J. Smit, Andrew Stubbs, Jeroen G. Noordzij, John P. Hays and Rianne Oostenbrink |
05-07-2021 | Micro organisms | Read Article |
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Rintatolimod Induces Antiviral Activities in Human Pancreatic Cancer Cells: Opening for an Anti-COVID-19 Opportunity in Cancer Patients? Dana A. M. Mustafa, Lawlaw Saida, Diba Latif, Leonoor V. Wimans, Willem de Koning, Lona Zeneyedpour, Theo M. Luider, Bernadette van den Hoogen and Casper H. J. van Eijck |
09-06-2021 | Cancers | Read Article |
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Reovirus mutant jin-3 exhibits lytic and immune-stimulatory effects in preclinical human prostate cancer models. of the Merbel AF, van der Horst G, van der Mark MH, Bots STF, van den Wollenberg DJM, de Ridder CMA, Ensign D, Aalders T, Erkens-Schulz S, van Montfoort N, Karthaus WR, Mehra N, Smits M, Schalken JA, van Weerden WM, Hoeben RC, van der Pluijm G |
01-06-2021 | Cancer Gene Ther. 2021 Jun 16 | Read Article |
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Identification, Validation, and Utilization of Immune Cells in Pancreatic Ductal Adenocarcinoma Based on Marker Genes Willem de Koning, Diba Latif, Yunlei Li, Casper H. J. van Eijck, Andrew P. Stubbs and Dana A. M. Mustafa |
27-04-2021 | Fonters in Immunology | Read Article |
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Personalizing Uncolytic Virotherapy for Glioblastoma: In Search of Biomarkers for Response. Stavrakaki E, Dirven, CMF, Lamfers MLM |
04-02-2021 | Cancers (Basel) | Read Article |
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Patient-derived tumour models for personalized therapeutics in urological cancers van de Merbel AF, van der Horst G, van der Pluijm G |
01-01-2021 | Nat Rev Urol. 2021 Jan; 18(1):33-45. | Read Article |
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Determinants of the efficacy of viro-immunotherapy: a review. de Graaf JF, Hubert M, Fouchier RAM, van den Hoogen BG |
01-12-2020 | Cytokine Growth Factor Rev. 2020 Dec;56:124-132 | Read Article |
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NanoGalaxy: Nanopore long-read sequencing data analysis in Galaxy Willem de Koning, Milad Miladi, Saskia Hiltemann, Astrid Heikema, John P Hays, Stephan Flemming, Marius van den Beek, Dana A Mustafa, Rolf Backofen, Björn Grüning, Andrew P Stubbs |
17-10-2020 | GigaScience | Read Article |
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Comparison of Illuminata versus Nanopore 16S rRNA Gene Sequencing of the Human Casal Microbiota Astrid P. Heikema, Deborah Horst-Kreft, Stefan A. Boers, Rick Jansen, Saskia D. Hiltemann, Willem de Koning, Robert Kraaij, Maria A. J. de Ridder, Chantal B. van Houten, Louis J. Bont, Andrew P. Stubbs and John P. Hays |
21-09-2020 | Genes | Read Article |
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Adenovirus Receptor Expression in Cancer and Its Multifaceted Role in Uncolytic Adenovirus Therapy Lobke C.M. Hensen, Rob C. Hoeben and Selas T.F. Bots |
17-09-2020 | International Journal of Molecular Science | Read Article |
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Determinants of the efficacy of viro-immunotherapy: A review J.F. de Graaf, M. Huberts, R.A.M. Fouchier, B.G. van den Hoogen |
06-09-2020 | Elsevier | Read Article |
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Dendritic cell vaccination and CD40-agonist combination therapy licenses T cell-dependent antitumour immunity in a pancreatic carcinoma murine model Lau, S.P. |
20-07-2020 | J Immunother Cancer | Read Article |
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Non-Human Primate-Derived Adenoviruses for Future Use as Uncolytic Agents? Selas T.F. Bots and Rob C. Hoeben |
08-07-2020 | International Journal of Molecular Science | Read Article |
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RNA from stabilised whole blood enablings more comprehensive immune gene expression profiling compared to RNA from peripheral blood mononucular cells Fleur van der Sijde, Yunlei Li, Rick Schraauwen, Willem de Koning, Casper H.J. van Eijck, Dana A.M. Mustafa |
26-06-2020 | PLOS ONE | Read Article |
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Developing oncolytic viruses for clinical use: A consortium approach. Kemp V, Lamfers MLM, van der Pluijm G, van den Hoogen BG, Hoeben RC |
10-06-2020 | Cytokine Growth Factor Rev. 2020 Dec;56:133-140 | Read Article |
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Lessons learn from the introduction of nanopore sequencing A. Heikema, W. de Koning, Y. Li, A. Stubbs, J.P. Hays |
04-06-2020 | Clinical Microbiology and Infection | Read Article |
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The pancreatic carcinoma: not immune to therapy, is it? Developments in immune therapy for ductal adenocarcinoma of the pancreas. Lau, S.P. |
26-09-2019 | Dutch Magazine for Oncology | Read Article |
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Armed oncolytic viruses: A kick-start for anti-tumour immunity. de Graaf, JF, de Vor L, Fouchier RAM, van den Hoogen BG. |
01-06-2018 | Cytokine Growth Factor Rev. 2018; 41:28-39. | Read Article |
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Rationally combining immunotherapy to improve efficacy of immune checkpoint blockkade in solid tumours Dammeijer, F. & Lau, S. P. |
28-06-2017 | Cytokine Growth Factor Rev | Read Article |
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Autologous Dendritic cells pulsed with allogenic tumour cell lysate induce tumour-reactive T-cell responses in pancreatic cancer patients: immunological analysis of an ongoing phase II study Lau, S.P. |
n/a | Clin Can Res (under revision) |
Published articles