Understanding how pancreatic cancer spreads
Most patients with pancreatic cancer die from metastatic disease rather than from the primary tumour itself. Little is known about the mechanisms that allow pancreatic cancer cells to spread. Understanding these processes could lead to ways of preventing metastasis and improving both survival and quality of life.
Researchers collect blood and tissue from primary pancreatic tumours and liver metastases. They isolate DNA to determine which genes are active and how those genes contribute to metastatic disease. The study also examines specific T cells in blood and the microbiome in saliva, both of which may influence the spread of cancer.
These findings are assessed alongside disease progression and the treatments received by each patient.